Determining the three-dimensional (3D) structure of ribonucleic acid (RNA) -small molecule ligand complex is crucial to understanding RNA molecular recognition. docking computer can, in principle, be used to predict the 3D structure of RNA-small molecule complex. Unfortunately, this retrospective analysis has shown that a scoring function that is usually used for prediction pose posing tend misclassify non-natives as the original, and vice versa.

Here, we use machine learning to train a set of classifiers that estimate the pose relatively “nativeness” of a set of RNA-ligand pose. At the heart of our approach is the use of the pose “fingerprint” (FP) which is a combination of a set of atoms FP, which individually encode local “RNA neighborhood” around the ligand atom. We found that the pose ranked by score classification of machine learning classifier, we are able to restore native-like pose better than when we rank based on score docking pose them.

By training leave-one-out and testing approach, we found that one of us could recover pose classifiers that are within 2.5 Å of the original pose in ~ 80% of the 80 cases we examined, and, on two separate validation set, we can recover pose as in ~ 60% of cases. we set classifier, which we refer to as RNAPosers, should find utility as a tool to aid in the prediction of RNA-ligand pose, and so we made RNAPosers open to academic

Novel coronavirus (COVID-19) pneumonia with negative detection of ribonucleic acid virus from nasopharyngeal swabs: a case report.

2019 new coronavirus disease (COVID-19) outbreak started in Wuhan, Hubei, China since December 2019 and cases of infection have been constantly reported in various countries. It is now clear that the SARS-CoV-2 coronavirus transmitted from human to human. Detection of nucleic acids is considered as the gold standard for diagnosis COVID-19. In this case report, we describe our experience in the detection of SARS-CoV-two of the patients were confirmed using nucleic acid testing of bronchoalveolar-lavage fluid (Balf) swabs.

We nasopharyngeal samples but not seriously ill SARS cases prize-COV- 2 infected man 46 years with fever, cough and chest tightness. We did use the sample Balf virus detection and imaging methods (CT) to confirm. Patients receiving the combination interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. Other drugs are also given to him in a combination of anti-inflammatory, regulation of gut microbes, eliminating phlegm, liver protection and prevention purposes pulmonary fibrosis.

We provide a supply of oxygen to her using a BiPAP ventilator and a high-flow oxygen humidification therapy instrument to facilitate respiration. Patients were cured and case reports described discharged.This support scheme effective drugs to treat SARS-CoV-2-infected patients and emphasizes the need for detection of viral genomes using samples Balf and significance in the diagnosis and prognosis of the disease.

Micro ribonucleic acids (miRNAs) are short non-coding RNA molecules that are responsible for the regulation of gene expression. They are involved in many pathophysiological process of a broad spectrum of diseases. Recent studies indicate their involvement in atrial fibrillation. They seem to be a potential biomarker screening for atrial fibrillation and treatment targets even for this arrhythmia.

ETHYL VIOLET AZIDE BROTH
E05-105-500g	Alphabiosciences	500 g	EUR 124

EUGONIC AGAR
E05-106-10kg	Alphabiosciences	10 kg	Ask for price

EUGONIC AGAR
E05-106-2Kg	Alphabiosciences	2 Kg	Ask for price

EUGONIC AGAR
E05-106-500g	Alphabiosciences	500 g	Ask for price

ENDO AGAR
E05-110-10kg	Alphabiosciences	10 kg	EUR 2381

ENDO AGAR
E05-110-2Kg	Alphabiosciences	2 Kg	EUR 557

ENDO AGAR
E05-110-500g	Alphabiosciences	500 g	EUR 188

APT AGAR
A01-101-10kg	Alphabiosciences	10 kg	EUR 1173

APT AGAR
A01-101-2Kg	Alphabiosciences	2 Kg	EUR 294

APT AGAR
A01-101-500g	Alphabiosciences	500 g	EUR 116

AGAR, BACTERIOLOGICAL
A01-102-10kg	Alphabiosciences	10 kg	EUR 1684

AGAR, BACTERIOLOGICAL
A01-102-2kg	Alphabiosciences	2kg	EUR 405

AGAR, BACTERIOLOGICAL
A01-102-500g	Alphabiosciences	500 g	EUR 146

AGAR, HIGH GEL
A01-102IHG-10kg	Alphabiosciences	10 kg	EUR 2219

AGAR, HIGH GEL
A01-102IHG-2Kg	Alphabiosciences	2 Kg	EUR 521

AGAR, HIGH GEL
A01-102IHG-500g	Alphabiosciences	500 g	EUR 178

AGAR,NOBLE
A01-102N-10kg	Alphabiosciences	10 kg	EUR 3910

AGAR,NOBLE
A01-102N-2kg	Alphabiosciences	2kg	EUR 889

AGAR,NOBLE
A01-102N-500g	Alphabiosciences	500 g	EUR 278

ALT. THIOGLYCOLLATE MED.
A01-103-10kg	Alphabiosciences	10 kg	Ask for price

ALT. THIOGLYCOLLATE MED.
A01-103-2Kg	Alphabiosciences	2 Kg	Ask for price

ALT. THIOGLYCOLLATE MED.
A01-103-500g	Alphabiosciences	500 g	Ask for price

AMIES BROTH WITH CHARCOAL
A01-104-10kg	Alphabiosciences	10 kg	Ask for price

AMIES BROTH WITH CHARCOAL
A01-104-2kg	Alphabiosciences	2kg	Ask for price

AMIES BROTH WITH CHARCOAL
A01-104-500g	Alphabiosciences	500 g	Ask for price

AMIES BROTH W/O CHARCOAL
A01-105-10kg	Alphabiosciences	10 kg	Ask for price

AMIES BROTH W/O CHARCOAL
A01-105-2Kg	Alphabiosciences	2 Kg	Ask for price

AMIES BROTH W/O CHARCOAL
A01-105-500g	Alphabiosciences	500 g	Ask for price

AZIDE BLOOD AGAR BASE
A01-113-10kg	Alphabiosciences	10 kg	EUR 2532

AZIDE BLOOD AGAR BASE
A01-113-2kg	Alphabiosciences	2kg	EUR 589

AZIDE BLOOD AGAR BASE
A01-113-500g	Alphabiosciences	500 g	EUR 197

AZIDE DEXTROSE BROTH
A01-114-10kg	Alphabiosciences	10 kg	EUR 868

AZIDE DEXTROSE BROTH
A01-114-2Kg	Alphabiosciences	2 Kg	EUR 228

AZIDE DEXTROSE BROTH
A01-114-500g	Alphabiosciences	500 g	EUR 98

ANAEROBIC AGAR
A01-115-10kg	Alphabiosciences	10 kg	EUR 2556

ANAEROBIC AGAR
A01-115-2kg	Alphabiosciences	2kg	EUR 595

ANAEROBIC AGAR
A01-115-500g	Alphabiosciences	500 g	EUR 198

A-1 MEDIUM
A01-116-10kg	Alphabiosciences	10 kg	EUR 1034

A-1 MEDIUM
A01-116-2Kg	Alphabiosciences	2 Kg	EUR 264

A-1 MEDIUM
A01-116-500g	Alphabiosciences	500 g	EUR 108

AGAROSE 25G-125G -500G
A01-118-10kg	Alphabiosciences	10 kg	Ask for price

AGAROSE 25G-125G -500G
A01-118-2kg	Alphabiosciences	2kg	Ask for price

AGAROSE 25G-125G -500G
A01-118-500g	Alphabiosciences	500 g	EUR 494

IL-2 Receptor ?, Human Recombinant
7100-10	Biovision		EUR 196

IL-2 Receptor ?, Human Recombinant
7100-50	Biovision		EUR 637

Human CellExp? IL-4 R?, Human Recombinant
7101-10	Biovision		EUR 229

Human CellExp? IL-4 R?, Human Recombinant
7101-50	Biovision		EUR 881

Human CellExp? IL-6 R?, Human Recombinant
7102-10	Biovision		EUR 207

Human CellExp? IL-6 R?, Human Recombinant
7102-50	Biovision		EUR 800

IL-9, Rat Recombinant
7103-10	Biovision		EUR 278

IL-9, Rat Recombinant
7103-50	Biovision		EUR 1132

IL-12p80, Human Recombinant
7104-10	Biovision		EUR 392

IL-12p80, Human Recombinant
7104-50	Biovision		EUR 1675

IL-17A, Mouse Recombinant
7105-10	Biovision		EUR 196

IL-17A, Mouse Recombinant
7105-50	Biovision		EUR 675

IL-17B, Human Recombinant
7106-10	Biovision		EUR 196

IL-17B, Human Recombinant
7106-50	Biovision		EUR 675

IL-17D, Human Recombinant
7107-10	Biovision		EUR 196

IL-17D, Human Recombinant
7107-50	Biovision		EUR 675

Human CellExp? IL-34, Human Recombinant
7108-10	Biovision		EUR 278

Human CellExp? IL-34, Human Recombinant
7108-50	Biovision		EUR 1132

IL-36RA, Human Recombinant
7109-10	Biovision		EUR 196

IL-36RA, Human Recombinant
7109-50	Biovision		EUR 675

IL-36?, Human Recombinant
7110-10	Biovision		EUR 278

IL-36?, Human Recombinant
7110-50	Biovision		EUR 1132

IL-36?, Human Recombinant
7111-10	Biovision		EUR 278

IL-36?, Human Recombinant
7111-50	Biovision		EUR 1132

Activin B, Human Recombinant
7112-10	Biovision		EUR 479

Activin B, Human Recombinant
7112-50	Biovision		EUR 2094

AITRL, Human Recombinant
7113-10	Biovision		EUR 251

AITRL, Human Recombinant
7113-50	Biovision		EUR 936

Amphiregulin, Human Recombinant
7114-10	Biovision		EUR 147

Amphiregulin, Human Recombinant
7114-50	Biovision		EUR 376

ANG-1, Human Recombinant
7115-10	Biovision		EUR 251

ANG-1, Human Recombinant
7115-50	Biovision		EUR 936

ANG-2, Human Recombinant
7116-10	Biovision		EUR 251

ANG-2, Human Recombinant
7116-50	Biovision		EUR 936

APRIL, Human Recombinant
7117-10	Biovision		EUR 311

APRIL, Human Recombinant
7117-50	Biovision		EUR 1300

APRIL, Mouse Recombinant
7118-10	Biovision		EUR 196

APRIL, Mouse Recombinant
7118-50	Biovision		EUR 675

Betacellulin, Murine Recombinant
7119-10	Biovision		EUR 196

Betacellulin, Murine Recombinant
7119-50	Biovision		EUR 675

Cardiotrophin-1, Murine Recombinant
7121-10	Biovision		EUR 278

Cardiotrophin-1, Murine Recombinant
7121-50	Biovision		EUR 1132

sCD100/Semaphorin-4D, Human Recombinant
7126-10	Biovision		EUR 251

sCD100/Semaphorin-4D, Human Recombinant
7126-50	Biovision		EUR 936

CTGFL/WISP-2, Human Recombinant
7129-10	Biovision		EUR 234

CTGFL/WISP-2, Human Recombinant
7129-50	Biovision		EUR 860

Human CellExp? DKK-1, Human Recombinant
7132-10	Biovision		EUR 278

Human CellExp? DKK-1, Human Recombinant
7132-50	Biovision		EUR 1132

Human CellExp? sDLL-1, Human Recombinant
7133-10	Biovision		EUR 207

Human CellExp? sDLL-1, Human Recombinant
7133-50	Biovision		EUR 675

Human CellExp? sDLL-4, Human Recombinant
7134-10	Biovision		EUR 207

Human CellExp? sDLL-4, Human Recombinant
7134-50	Biovision		EUR 675

Eotaxin-2/CCL24, murine recombinant
7137-10	Biovision		EUR 207

Eotaxin-2/CCL24, murine recombinant
7137-50	Biovision		EUR 675

Eotaxin-3/CCL26, human recombinant
7138-10	Biovision		EUR 207

Eotaxin-3/CCL26, human recombinant
7138-50	Biovision		EUR 675

Human CellExp? Fetuin A/ASHG, Human Recombinant
7142-10	Biovision		EUR 153

Human CellExp? Fetuin A/ASHG, Human Recombinant
7142-50	Biovision		EUR 381

Histone H3 Peptide, biotin conjugate
7143-01	Biovision		EUR 240

Histone H3 Peptide, biotin conjugate
7143-1	Biovision		EUR 1132

Histone H4 Peptide, tetra-acetylated, biotin conjugate
7144-01	Biovision		EUR 240

Histone H4 Peptide, tetra-acetylated, biotin conjugate
7144-1	Biovision		EUR 1132

FGF-5, human recombinant
7147-10	Biovision		EUR 142

FGF-5, human recombinant
7147-50	Biovision		EUR 359

FGF-6, human recombinant
7148-10	Biovision		EUR 207

FGF-6, human recombinant
7148-50	Biovision		EUR 675

FGF-16, human recombinant
7149-10	Biovision		EUR 207

FGF-16, human recombinant
7149-50	Biovision		EUR 675

FGF-17, human recombinant
7150-10	Biovision		EUR 207

FGF-17, human recombinant
7150-50	Biovision		EUR 675

FGF-23, human recombinant
7151-10	Biovision		EUR 229

FGF-23, human recombinant
7151-50	Biovision		EUR 860

GASP-1, human recombinant
7152-10	Biovision		EUR 229

GASP-1, human recombinant
7152-50	Biovision		EUR 833

GCP-2 (CXCL6), human recombinant
7153-10	Biovision		EUR 207

GCP-2 (CXCL6), human recombinant
7153-50	Biovision		EUR 675

BMP-9/GDF-2, human recombinant
7154-10	Biovision		EUR 278

BMP-9/GDF-2, human recombinant
7154-50	Biovision		EUR 1132

BMP-11/GDF-11, human recombinant
7155-10	Biovision		EUR 240

BMP-11/GDF-11, human recombinant
7155-50	Biovision		EUR 860

Gremlin-1, human recombinant
7159-10	Biovision		EUR 142

Gremlin-1, human recombinant
7159-50	Biovision		EUR 359

ICAM-1, human recombinant
7161-10	Biovision		EUR 142

ICAM-1, human recombinant
7161-50	Biovision		EUR 359

IFN-?1, human recombinant
7162-10	Biovision		EUR 207

IFN-?1, human recombinant
7162-50	Biovision		EUR 735

IFN-?2, human recombinant
7163-10	Biovision		EUR 207

IFN-?2, human recombinant
7163-50	Biovision		EUR 675

IGF-BP2, human recombinant
7165-10	Biovision		EUR 251

IGF-BP2, human recombinant
7165-50	Biovision		EUR 936

IGF-BP4, human recombinant
7166-10	Biovision		EUR 251

IGF-BP4, human recombinant
7166-50	Biovision		EUR 936

IGF-BP7, human recombinant
7167-10	Biovision		EUR 207

IGF-BP7, human recombinant
7167-50	Biovision		EUR 675

MCP-5/CCL12, murine recombinant
7168-10	Biovision		EUR 207

MCP-5/CCL12, murine recombinant
7168-50	Biovision		EUR 675

MIP-1?/CCL3, human recombinant
7173-10	Biovision		EUR 207

MIP-1?/CCL3, human recombinant
7173-50	Biovision		EUR 675

MIP-1?/CCL9/10, murine recombinant
7174-10	Biovision		EUR 207

MIP-1?/CCL9/10, murine recombinant
7174-50	Biovision		EUR 675

MIP-3/CCL23, human recombinant
7175-10	Biovision		EUR 207

MIP-3/CCL23, human recombinant
7175-50	Biovision		EUR 675

Nesfatin-1, human recombinant
7178-10	Biovision		EUR 137

Nesfatin-1, human recombinant
7178-50	Biovision		EUR 272

Human CellExp? PECAM-1, Human Recombinant
7184-10	Biovision		EUR 153

Human CellExp? PECAM-1, Human Recombinant
7184-50	Biovision		EUR 381

PF-4/CXCL4, murine recombinant
7187-10	Biovision		EUR 207

PF-4/CXCL4, murine recombinant
7187-50	Biovision		EUR 675

R-Spondin-1, human recombinant
7189-10	Biovision		EUR 207

R-Spondin-1, human recombinant
7189-50	Biovision		EUR 675

R-Spondin-2, human recombinant
7190-10	Biovision		EUR 207

R-Spondin-2, human recombinant
7190-50	Biovision		EUR 675

R-Spondin-3, human recombinant
7191-10	Biovision		EUR 207

R-Spondin-3, human recombinant
7191-50	Biovision		EUR 675

Relaxin-2, human recombinant
7194-10	Biovision		EUR 207

Relaxin-2, human recombinant
7194-50	Biovision		EUR 675

Relaxin-3, human recombinant
7195-10	Biovision		EUR 207

Relaxin-3, human recombinant
7195-50	Biovision		EUR 675

SDF-1?/CXCL2, rat recombinant
7199-10	Biovision		EUR 207

SDF-1?/CXCL2, rat recombinant
7199-50	Biovision		EUR 675

SDF-1?/CXCL2, rat recombinant
7200-10	Biovision		EUR 207

SDF-1?/CXCL2, rat recombinant
7200-50	Biovision		EUR 675

Semaphorin 3A, human recombinant
7201-10	Biovision		EUR 207

Semaphorin 3A, human recombinant
7201-50	Biovision		EUR 675

sTRAIL Receptor-1/DR4, human recombinant
7206-10	Biovision		EUR 153

sTRAIL Receptor-1/DR4, human recombinant
7206-50	Biovision		EUR 381

VAP-1, human recombinant
7210-10	Biovision		EUR 321

VAP-1, human recombinant
7210-50	Biovision		EUR 1186

Human CellExp? VCAM-1, Human Recombinant
7211-10	Biovision		EUR 142

Human CellExp? VCAM-1, Human Recombinant
7211-50	Biovision		EUR 381

TAFA-2, human recombinant
7213-10	Biovision		EUR 207

TAFA-2, human recombinant
7213-50	Biovision		EUR 675

Thymosin-?4, human recombinant
7216-10	Biovision		EUR 131

Thymosin-?4, human recombinant
7216-50	Biovision		EUR 272

TL-1A, human recombinant
7219-10	Biovision		EUR 207

TL-1A, human recombinant
7219-50	Biovision		EUR 675

Human CellExp? TLR-3, Human Recombinant
7220-10	Biovision		EUR 207

Human CellExp? TLR-3, Human Recombinant
7220-50	Biovision		EUR 675

The purpose of the review of this article is to summarize the latest knowledge about miRNA molecules and their relationship to the pathophysiology, diagnosis and treatment of atrial fibrillation.