
RNAPosers: Machine Learning Classifiers for Ribonucleic Acid-Ligand Poses
Determining the three-dimensional (3D) structure of ribonucleic acid (RNA) -small molecule ligand complex is crucial to understanding RNA molecular recognition. docking computer can, in principle, be used to predict the 3D structure of RNA-small molecule complex. Unfortunately, this retrospective analysis has shown that a scoring function that is usually used for prediction pose posing tend misclassify non-natives as the original, and vice versa.
Here, we use machine learning to train a set of classifiers that estimate the pose relatively “nativeness” of a set of RNA-ligand pose. At the heart of our approach is the use of the pose “fingerprint” (FP) which is a combination of a set of atoms FP, which individually encode local “RNA neighborhood” around the ligand atom. We found that the pose ranked by score classification of machine learning classifier, we are able to restore native-like pose better than when we rank based on score docking pose them.
By training leave-one-out and testing approach, we found that one of us could recover pose classifiers that are within 2.5 Å of the original pose in ~ 80% of the 80 cases we examined, and, on two separate validation set, we can recover pose as in ~ 60% of cases. we set classifier, which we refer to as RNAPosers, should find utility as a tool to aid in the prediction of RNA-ligand pose, and so we made RNAPosers open to academic

Novel coronavirus (COVID-19) pneumonia with negative detection of ribonucleic acid virus from nasopharyngeal swabs: a case report.
2019 new coronavirus disease (COVID-19) outbreak started in Wuhan, Hubei, China since December 2019 and cases of infection have been constantly reported in various countries. It is now clear that the SARS-CoV-2 coronavirus transmitted from human to human. Detection of nucleic acids is considered as the gold standard for diagnosis COVID-19. In this case report, we describe our experience in the detection of SARS-CoV-two of the patients were confirmed using nucleic acid testing of bronchoalveolar-lavage fluid (Balf) swabs.
We nasopharyngeal samples but not seriously ill SARS cases prize-COV- 2 infected man 46 years with fever, cough and chest tightness. We did use the sample Balf virus detection and imaging methods (CT) to confirm. Patients receiving the combination interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. Other drugs are also given to him in a combination of anti-inflammatory, regulation of gut microbes, eliminating phlegm, liver protection and prevention purposes pulmonary fibrosis.
We provide a supply of oxygen to her using a BiPAP ventilator and a high-flow oxygen humidification therapy instrument to facilitate respiration. Patients were cured and case reports described discharged.This support scheme effective drugs to treat SARS-CoV-2-infected patients and emphasizes the need for detection of viral genomes using samples Balf and significance in the diagnosis and prognosis of the disease.
Micro ribonucleic acids (miRNAs) are short non-coding RNA molecules that are responsible for the regulation of gene expression. They are involved in many pathophysiological process of a broad spectrum of diseases. Recent studies indicate their involvement in atrial fibrillation. They seem to be a potential biomarker screening for atrial fibrillation and treatment targets even for this arrhythmia.
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7100-10 | Biovision | EUR 196 |
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7102-10 | Biovision | EUR 207 |
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7104-10 | Biovision | EUR 392 |
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7107-10 | Biovision | EUR 196 |
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7107-50 | Biovision | EUR 675 |
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7108-10 | Biovision | EUR 278 |
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7108-50 | Biovision | EUR 1132 |
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7109-10 | Biovision | EUR 196 |
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7109-50 | Biovision | EUR 675 |
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7110-10 | Biovision | EUR 278 |
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7110-50 | Biovision | EUR 1132 |
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7111-10 | Biovision | EUR 278 |
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7111-50 | Biovision | EUR 1132 |
![]() Activin B, Human Recombinant |
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7112-10 | Biovision | EUR 479 |
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7112-50 | Biovision | EUR 2094 |
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7113-10 | Biovision | EUR 251 |
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7114-10 | Biovision | EUR 147 |
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7114-50 | Biovision | EUR 376 |
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7115-10 | Biovision | EUR 251 |
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7115-50 | Biovision | EUR 936 |
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7116-10 | Biovision | EUR 251 |
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7126-10 | Biovision | EUR 251 |
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7129-10 | Biovision | EUR 234 |
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7129-50 | Biovision | EUR 860 |
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7132-10 | Biovision | EUR 278 |
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7134-10 | Biovision | EUR 207 |
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7134-50 | Biovision | EUR 675 |
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7137-10 | Biovision | EUR 207 |
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7137-50 | Biovision | EUR 675 |
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7138-10 | Biovision | EUR 207 |
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7138-50 | Biovision | EUR 675 |
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7142-10 | Biovision | EUR 153 |
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7142-50 | Biovision | EUR 381 |
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7143-01 | Biovision | EUR 240 |
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7143-1 | Biovision | EUR 1132 |
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7144-01 | Biovision | EUR 240 |
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7144-1 | Biovision | EUR 1132 |
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7147-10 | Biovision | EUR 142 |
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7147-50 | Biovision | EUR 359 |
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7148-10 | Biovision | EUR 207 |
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7148-50 | Biovision | EUR 675 |
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7149-10 | Biovision | EUR 207 |
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7149-50 | Biovision | EUR 675 |
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7150-10 | Biovision | EUR 207 |
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7150-50 | Biovision | EUR 675 |
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7151-10 | Biovision | EUR 229 |
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7151-50 | Biovision | EUR 860 |
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7152-10 | Biovision | EUR 229 |
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7152-50 | Biovision | EUR 833 |
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7153-10 | Biovision | EUR 207 |
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7153-50 | Biovision | EUR 675 |
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7154-10 | Biovision | EUR 278 |
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7154-50 | Biovision | EUR 1132 |
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7155-10 | Biovision | EUR 240 |
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7155-50 | Biovision | EUR 860 |
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7159-10 | Biovision | EUR 142 |
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7159-50 | Biovision | EUR 359 |
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7161-10 | Biovision | EUR 142 |
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7161-50 | Biovision | EUR 359 |
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7162-10 | Biovision | EUR 207 |
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7162-50 | Biovision | EUR 735 |
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7163-10 | Biovision | EUR 207 |
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7163-50 | Biovision | EUR 675 |
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7165-10 | Biovision | EUR 251 |
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7165-50 | Biovision | EUR 936 |
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7166-10 | Biovision | EUR 251 |
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7166-50 | Biovision | EUR 936 |
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7167-10 | Biovision | EUR 207 |
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7167-50 | Biovision | EUR 675 |
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7168-10 | Biovision | EUR 207 |
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7168-50 | Biovision | EUR 675 |
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7173-10 | Biovision | EUR 207 |
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7173-50 | Biovision | EUR 675 |
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7174-10 | Biovision | EUR 207 |
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7174-50 | Biovision | EUR 675 |
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7175-10 | Biovision | EUR 207 |
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7175-50 | Biovision | EUR 675 |
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7178-10 | Biovision | EUR 137 |
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7178-50 | Biovision | EUR 272 |
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7184-10 | Biovision | EUR 153 |
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7184-50 | Biovision | EUR 381 |
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7187-10 | Biovision | EUR 207 |
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7187-50 | Biovision | EUR 675 |
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7189-10 | Biovision | EUR 207 |
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7189-50 | Biovision | EUR 675 |
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7190-10 | Biovision | EUR 207 |
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7190-50 | Biovision | EUR 675 |
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7191-10 | Biovision | EUR 207 |
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7191-50 | Biovision | EUR 675 |
![]() Relaxin-2, human recombinant |
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7194-10 | Biovision | EUR 207 |
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7194-50 | Biovision | EUR 675 |
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7195-10 | Biovision | EUR 207 |
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7195-50 | Biovision | EUR 675 |
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7199-10 | Biovision | EUR 207 |
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7199-50 | Biovision | EUR 675 |
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7200-10 | Biovision | EUR 207 |
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7200-50 | Biovision | EUR 675 |
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7201-10 | Biovision | EUR 207 |
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7201-50 | Biovision | EUR 675 |
![]() sTRAIL Receptor-1/DR4, human recombinant |
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7206-10 | Biovision | EUR 153 |
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7206-50 | Biovision | EUR 381 |
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7210-10 | Biovision | EUR 321 |
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7210-50 | Biovision | EUR 1186 |
![]() Human CellExp? VCAM-1, Human Recombinant |
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7211-10 | Biovision | EUR 142 |
![]() Human CellExp? VCAM-1, Human Recombinant |
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7211-50 | Biovision | EUR 381 |
![]() TAFA-2, human recombinant |
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7213-10 | Biovision | EUR 207 |
![]() TAFA-2, human recombinant |
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7213-50 | Biovision | EUR 675 |
![]() Thymosin-?4, human recombinant |
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7216-10 | Biovision | EUR 131 |
![]() Thymosin-?4, human recombinant |
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7216-50 | Biovision | EUR 272 |
![]() TL-1A, human recombinant |
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7219-10 | Biovision | EUR 207 |
![]() TL-1A, human recombinant |
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7219-50 | Biovision | EUR 675 |
![]() Human CellExp? TLR-3, Human Recombinant |
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7220-10 | Biovision | EUR 207 |
![]() Human CellExp? TLR-3, Human Recombinant |
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7220-50 | Biovision | EUR 675 |
The purpose of the review of this article is to summarize the latest knowledge about miRNA molecules and their relationship to the pathophysiology, diagnosis and treatment of atrial fibrillation.
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