“Zooming in” on Glioblastoma: Understanding Tumor Heterogeneity and its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing

“Zooming in” on Glioblastoma: Understanding Tumor Heterogeneity and its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing

Glioblastoma (GBM) is the most common primary brain malignancy in adults and one of the most aggressive of all cancers in humans. It is very repetitive and treatment-resistant, largely because the infiltrative nature and inter- and intratumoral heterogeneity. This heterogeneity requires different landscape genomics and cell types within and between the tumor and the tumor microenvironment (TME). In the GBM, is the driving resistance heterogeneity of treatment, recurrence, and prognosis is poor, represent a major obstacle to personalized medicine.

Over the past decade, the sequencing technology has facilitated a deeper understanding of GBM heterogeneity by “zooming in” more progressive on tumor genomics and transcriptomics. initial efforts to use mass ribonucleic acid (RNA) sequencing, which examined the combined gene expression of tumor specimens as a whole. While innovative at the time, this bulk RNAseq mask important contribution of sub-populations of different tumor’s gene expression as a whole.

This work evolved into mass use RNA sequencing on tumor subsections anatomically and spatially distinct, previously unappreciated complexity exhibited genome of GBM. The revolutionary next step forward has been the emergence of a single cell RNA sequencing (scRNAseq), which examined the gene expression at the single cell level. scRNAseq has enabled us to understand in detail the heterogeneity GBM unprecedented.

We review studies of seminal in the development of our understanding of GBM heterogeneity, with a focus on scRNAseq and insight that have been provided in the understanding of GBM tumor mass, peritumoral space, and TME. We highlight the preclinical and clinical implications of this work and consider the potential impact of neuro-oncology, and to improve patient outcomes through personalized medicine.

"Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing
“Zooming in” on Glioblastoma: Understanding Tumor Heterogeneity and its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing

[Knockdown of Fez family of zinc finger protein 1 antisense ribonucleic acid 1 (FEZF1-AS1) inhibits invasion and migration of esophageal squamous cell carcinoma cells by blocking the JAK2 / STAT3 pathway]

Objective To investigate the relationship between the long chain of non-coding RNA Fez family of zinc protein finger 1 antisense ribonucleic acid 1 (FEZF1-AS1) and invasion, migration and Janus kinase 2 / signal transducer and activator of transcription 3 (JAK2 / STAT3) signaling pathway in carcinoma squamous cell (ESCC) cells of the esophagus. Methods The expression ‘of FEZF1-AS1 in cancer tissues and cell lines ESCC ESCC was detected by real-time quantitative PCR.

After knocking out FEZF1-AS1 of KYSE150 and KYSE510 cells with expression vectors lentiviral built, changes in cell cycle were detected by flow cytometry, the ability of cell proliferation by colony test formations, the ability of cell invasion by TranswellTM invasion assay, the ability of cell migration by TranswellTM migration and early test, and the level of phosphorylated proteins JAK2 and STAT3 (p-STAT3) by Western blotting.

Influenza A H1 Antibody

abx021964-1mg 1 mg
EUR 1111.2

Influenza A H1 Antibody

abx021965-1mg 1 mg
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Influenza A H1 Antibody

abx021966-1mg 1 mg
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Influenza A H1 Antibody

abx021967-1mg 1 mg
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Influenza A H1 Antibody

abx021968-1mg 1 mg
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Influenza A H1 Antibody

abx021969-1mg 1 mg
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Influenza A H1 Antibody

abx021970-1mg 1 mg
EUR 1161.6

Influenza A H1 Antibody

abx023068-100ug 100 ug
EUR 1011.6

Core Panel Multi-Tumor control slides

TS900 Set of 5
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TS900-25 Set of 25
EUR 582

Breast Panel Multi-Tumor control slides

TS901 Set of 5
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Breast Panel Multi-Tumor control slides

TS901-25 Set of 25
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Goat IgG (-ve control for flow cytometry) (isotype control)

20011-100 100 test
EUR 123.6

BSA Control for AGE-BSA

35R-AA007 10 mg
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BSA Control for Age-BSA

2221-BSA
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Flow Control Fitting for Blowgun

FLY1252 EACH
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Flow Control Fitting for Flypad

FLY1254 EACH
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Recombinant Purified Hemagglutinin Influenza A Virus (H11N2; A/duck/Yangzhou/906/2002) protein control for Western

H11N2-01-C 100 ul
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NATtrol Influenza A/B Positive Control (6 x 0.5mL)

NATFLUAB-6C 6 x 0.5mL
EUR 272.16
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Influenza A HA H1 antibody

10-7839 500 ug
EUR 349.2
Description: Mouse monoclonal Influenza A haemagglutinin H1 antibody

Influenza A HA H1 antibody

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EUR 349.2
Description: Mouse monoclonal Influenza A haemagglutinin H1 antibody

Influenza A H1 (Swine) Peptide

abx060603-005mg 0.05 mg
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Apolipoprotein A-Il, Human Plasma protein control for WB

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Control for Ckit, 6 samples (1.5mm)

CKIT061 1
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HRC081 1
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SLLK, Control Peptide for TSP1 Inhibitor

HY-P0301 1mg
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PRC061 1
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PAS/Glycogen, For Digestion (Control Slides)

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TCS0024-5 5 Slides
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Control/Blocking peptide for Human WNT5a

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V8785-100UG 100ug
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Deer IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20024-2 100 ug
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MDZ046 6 X 0.5 mL
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M2E15-P 100 ug
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Rabbit anti Arabidopsis thaliana Actin-1 (ACT1) IgG affinity pure, loading control for WB

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20008-1-100 100 tests
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20009-1-100 100 tests
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Human Apolipoprotein B protein control for WB

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Rec. Human CD21 protein control for WB

CD21-C 100 ul
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CP16-C 100 ul
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ADA11-C 100 ul
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OVA11-C 100 ul
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Mouse negative control sera (purified) for IHC

NCM802M 7 ml
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Control/Blocking peptide for Ephrin-B2 antibody

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MEHCON 100 uL
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Haptoglobin Human Plasma protein control for WB

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HPEX16-C 100 ul
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Purified Flagellin (salmonella) protein control for WB

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HY-P0301A 5mg
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Goat polyclonal antibody for Influenza A

1321 1 ml
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Description: This is goat polyclonal antibody against Influenza A matrix protein for WB, ELISA.

Goat polyclonal antibody for Influenza A

1323 1 ml
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Description: This is FITC conjugated goat polyclonal antibody against Influenza A matrix protein for WB, ELISA.

Goat polyclonal antibody for Influenza A

1327 1 ml
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Description: This is Biotin conjugated goat polyclonal antibody against Influenza A matrix protein for WB, ELISA.

Mouse antibody for Influenza A virus

1333 100 ug
EUR 431.93
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Mouse antibody for Influenza A virus

1343 100 ug
EUR 431.93
Description: This is Mouse monoclonal FITC conjugated antibody against Influenza A virus NP for WB, ELISA.

Goat polyclonal antibody for Influenza A

1301 1 ml
EUR 327.53
Description: This is goat polyclonal antibody against Influenza A virions, H1N1 for WB, ELISA.

Goat polyclonal antibody for Influenza A

1303 1 ml
EUR 347.1
Description: This is FITC conjugated goat polyclonal antibody against Influenza A virions, H1N1 for WB, ELISA.

Goat polyclonal antibody for Influenza A

1304 1 ml
EUR 373.2
Description: This is HRP conjugated goat polyclonal antibody against Influenza A virions, H3N2 for WB, ELISA.

Goat polyclonal antibody for Influenza A

1307 1 ml
EUR 347.1
Description: This is Biotin conjugated goat polyclonal antibody against Influenza A virions, H1N1 for WB, ELISA.

Goat polyclonal antibody for Influenza A

1311 1 ml
EUR 327.53
Description: This is goat polyclonal antibody against Influenza A virions, H3N2 for WB, ELISA.

Goat polyclonal antibody for Influenza A

1313 1 ml
EUR 347.1
Description: This is FITC conjugated goat polyclonal antibody against Influenza A virions, H3N2 for WB, ELISA.

Goat polyclonal antibody for Influenza A

1314 1 ml
EUR 373.2
Description: This is HRP conjugated goat polyclonal antibody against Influenza A matrix protein for WB, ELISA.

Goat polyclonal antibody for Influenza A

1317 1 ml
EUR 347.1
Description: This is Biotin conjugated goat polyclonal antibody against Influenza A virions, H3N2 for WB, ELISA.

Goat polyclonal antibody for Influenza A

1974 1 ml
EUR 386.26
Description: This is HRP conjugated goat polyclonal antibody against Influenza A virions, H1N1 for WB, ELISA.

MBD1 Polyclonal Antibody

A-1006
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5-Methylcytosine (5-mC) Monoclonal Antibody [33D3]

A-1014
  • EUR 721.20
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  • EUR 239.80
  • EUR 456.50
  • 100 µg
  • 10 ug
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5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody [HMC/4D9]

A-1018
  • EUR 702.06
  • EUR 82.50
  • EUR 239.80
  • EUR 443.30
  • 100 µg
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PRDM4 Polyclonal Antibody

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EZH1 Polyclonal Antibody

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HSF1 Polyclonal Antibody

A-2401
  • EUR 905.64
  • EUR 235.40
  • EUR 423.50
  • EUR 574.20
  • 200 µl
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PRMT3 Polyclonal Antibody

A-3003
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  • 100 µg
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SET1 Polyclonal Antibody

A-3011
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SET07 Polyclonal Antibody

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LSD1 Polyclonal Antibody

A-3018
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HDAC10 Polyclonal Antibody

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PCAF Polyclonal Antibody

A-4012
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  • 100 µg
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Histone H3K9ac (Acetyl H3K9) Polyclonal Antibody

A-4022
  • EUR 555.90
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  • EUR 336.60
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  • 50 µl
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Histone H3K14ac (Acetyl H3K14) Polyclonal Antibody

A-4023
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  • 50 µl
  • 25 ul
  • 50 ul
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Histone H3K18ac (Acetyl H3K18) Polyclonal Antibody

A-4024
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  • EUR 336.60
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  • 50 µl
  • 25 ul
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Histone H3K23ac (Acetyl H3K23) Polyclonal Antibody

A-4025
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  • EUR 383.90
  • 50 µg
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K56ac (Acetyl H3K56) Polyclonal Antibody

A-4026
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  • EUR 336.60
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  • 50 µl
  • 25 ul
  • 50 ul
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Histone H3K4me1 (H3K4 Monomethyl) Polyclonal Antibody

A-4031
  • EUR 555.90
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  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K4me2 (H3K4 Dimethyl) Polyclonal Antibody

A-4032
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  • EUR 336.60
  • EUR 383.90
  • 50 µg
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  • 50 ul
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Histone H3K4me3 (H3K4 Trimethyl) Polyclonal Antibody

A-4033
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  • EUR 177.10
  • EUR 342.10
  • EUR 479.60
  • 50 µl
  • 25 ul
  • 50 ul
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Histone H3K9me1 (H3K9 Monomethyl) Polyclonal Antibody

A-4034
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  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
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Histone H3K9me2 (H3K9 Dimethyl) Polyclonal Antibody

A-4035
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  • EUR 336.60
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  • 50 ul
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Histone H3K9me3 (H3K9 Trimethyl) Polyclonal Antibody

A-4036
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  • EUR 173.80
  • EUR 336.60
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  • 50 µl
  • 25 ul
  • 50 ul
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Histone H3K27me1 (H3K27 Monomethyl) Polyclonal Antibody

A-4037
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  • EUR 336.60
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  • 50 µl
  • 25 ul
  • 50 ul
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Histone H3K27me2 (H3K27 Dimethyl) Polyclonal Antibody

A-4038
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27me3 (H3K27 Trimethyl) Polyclonal Antibody

A-4039
  • EUR 555.90
  • EUR 177.10
  • EUR 342.10
  • EUR 479.60
  • 50 µl
  • 25 ul
  • 50 ul
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Histone H3K36me1 (H3K36 Monomethyl) Polyclonal Antibody

A-4040
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
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Histone H3K36me2 (H3K36 Dimethyl) Polyclonal Antibody

A-4041
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K36me3 (H3K36 Trimethyl) Polyclonal Antibody

A-4042
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K79me1 (H3K79 Monomethyl) Polyclonal Antibody

A-4043
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K79me2 (H3K79 Dimethyl) Polyclonal Antibody

A-4044
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K79me3 (H3K79 Trimethyl) Polyclonal Antibody

A-4045
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H4K20me1 (H4K20 Monomethyl) Polyclonal Antibody

A-4046
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H4K20me2 (H4K20 Dimethyl) Polyclonal Antibody

A-4047
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H4K20me3 (H4K20 Trimethyl) Polyclonal Antibody

A-4048
  • EUR 555.90
  • EUR 173.80
  • EUR 302.50
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27ac (Acetyl H3K27) Polyclonal Antibody

A-4708
  • EUR 813.42
  • EUR 173.80
  • EUR 299.20
  • EUR 510.40
  • 100 µl
  • 25 ul
  • 50 ul
  • 100 ul

Results FEZF1-AS1 are highly expressed in cancer tissues ESCC and FEZF1-AS1 expression in cells KYSE510 KYSE150 and higher than that in normal esophageal squamous epithelial cells. Upon knockdown FEZF1-AS1 expression, cell cycle and proliferation of cancer cells ESCC did not change obviously, but cell invasion and migration was significantly inhibited, and the protein levels decreased JAK2 and p-STAT3 protein increases. Conclusion FEZF1-AS1 knockdown blocks JAK2 / STAT3 pathway and inhibits cell invasion and migration of ESCC.

Kathleen

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